fentanyl, cyproheptadine. Both increases toxicity from the other by pharmacodynamic synergism. Modify Therapy/Check Carefully. Coadministration of fentanyl with anticholinergics may possibly increase risk for urinary retention and/or serious constipation, which may result in paralytic ileus.
Coadministration with CYP3A4 substrates, notably Individuals with a slender therapeutic index, may end up in lowered concentrations and loss of efficacy. If struggling to stay away from coadministration, watch CYP3A4 substrate levels and alter dose as required.
fentanyl iontophoretic transdermal system and fentanyl both equally improve sedation. Stay clear of or Use Alternate Drug. Restrict use to patients for whom substitute treatment options are insufficient
olanzapine/samidorphan decreases effects of fentanyl by pharmacodynamic antagonism. Contraindicated. Samidorphan elicits opioid antagonistic effects and increases risk of precipitating acute opioid withdrawal in patients dependent on opioids.
No sizeable interaction is expected with concurrent use of opioid analgesics and alvimopan in patients who obtained opioid analgesics for 7 or much less consecutive times ahead of alvimopan.
schisandra will enhance the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
fentanyl, triprolidine. Both raises toxicity in the other by pharmacodynamic synergism. Modify Therapy/Check Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or intense constipation, which may cause paralytic ileus.
Opioid-induced hyperalgesia (OIH) happens when opioid analgesic paradoxically causes rise fentanyl patch in pain, or rise in sensitivity to pain; this problem differs from tolerance, that's the need for escalating doses of opioids to maintain a defined effect
fentanyl and esketamine intranasal equally raise sedation. Stay clear of or Use Alternate Drug. Restrict use to patients for whom choice treatment options are inadequate
somapacitan will reduce the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Warn patients not to drive or operate dangerous machinery Except if These are tolerant to effects of drug and know the way they're going to react to medication
sotorasib will decrease the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. If use is unavoidable, refer to the prescribing information in the CYP3A4 substrate for dosage modifications
anastrozole will increase the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unknown.
If coadministration of CYP3A4 inhibitors with fentanyl is critical, observe patients for respiratory depression and sedation at frequent intervals and consider fentanyl dose changes right until stable drug effects are attained.